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Patented Formula · 500mg Dose · Lab Verified
A Patented Urolithin A Formula You Won't Find Anywhere Else
Patented Formula Verified LIVE
Our proprietary Urolithin A formulation is patent-protected. Every batch HPLC-verified at an independent ISO-certified lab.
This isn't another generic Urolithin A off a factory line. Foundation Gummies use a patented formulation exclusive to Onset — engineered for superior bioavailability at the full 500mg clinical dose. You won't find this formula on Amazon, at a competitor, or anywhere else. It's ours.*
Our Urolithin A formulation is patent-protected and exclusive to Foundation Gummies. No other brand can sell this exact formula — it was engineered from the ground up for maximum cellular uptake.
The exact dose used in the ATLAS trial (Cell Reports Medicine, 2022). HPLC-verified every batch at an independent ISO-certified lab. Not estimated. Not blended. Verified.
Foundation Gummies are sold exclusively through Onset. No third-party sellers. No resellers. No risk of counterfeits. When 6 of 10 Amazon UA products fail lab testing, we chose a different path.
~60% of adults can't produce Urolithin A from food. Our patented formulation is engineered to bypass the gut microbiome bottleneck — delivering 6× higher plasma levels than pomegranate juice alone.*
View Our Patent-Backed Lab Results
Tap to see the verified potency of our exclusive formula
617 clinicians, including integrative and sports medicine practitioners, share this on FrontrowMD.
Clinicians who shared this product
Dr. James Harmon
Austin, TX
Dr. Megan Barry
Charlottesville, VA
Dr. Melissa Dixon
Neptune, NJ
Dr. Diane Davis
Allen, TX
Dr. Regina O'Brien, MD
Oak Park, IL
We Don't Hide Behind Labels.
We Open the Lab Door.
Watch our formulators break down exactly what's in every gummy — the sourcing, the dose verification, and why 6 out of 10 competitors fail independent testing.
How We Test Every Batch to 500mg
Our lab director walks through the third-party HPLC testing process that verifies full-dose Urolithin A in every production run — before it ships.
Why Most Urolithin A Fails — and Ours Doesn't
Our formulation scientist explains the sourcing and stability challenges that cause 60% of products to fail independent lab testing — and how we solve them.
What Happens Inside Your Cells When You Take Urolithin A
Your mitochondria power every cell. Urolithin A clears the damaged ones so your body can rebuild. Here's how — step by step.
Mitochondria Accumulate Damage
Over time — accelerated by aging, stress, and inactivity — your mitochondria accumulate oxidative damage. They produce less ATP (energy) and more reactive oxygen species (inflammation). By your 40s, this decline is measurable.
Urolithin A Activates the PINK1/Parkin Pathway
When you take 500mg of Urolithin A, it crosses into cells and activates mitophagy via the PINK1/Parkin signaling cascade — the same selective recycling pathway discovered in the foundational 2016 Nature Medicine study. This tags damaged mitochondria for removal.
Damaged Mitochondria Are Cleared
Tagged mitochondria are engulfed by autophagosomes and broken down. The cell's energy grid goes from cluttered and inefficient to clean and ready. In the ATLAS trial, this process was confirmed by changes in plasma acylcarnitines and CRP — both dropped significantly.
New, Functional Mitochondria Are Built
With damaged units cleared, mitochondrial biogenesis replaces them with healthy, fully functional mitochondria. The result: ~12% more muscle strength in 4 months (ATLAS, Cell Reports Medicine, 2022). Better cellular energy. Lower inflammation. No change in exercise required.*
What to Expect — A Clinical Timeline
Urolithin A is not a stimulant. Benefits build over weeks as mitophagy clears damaged mitochondria and your cells rebuild. Here's what the peer-reviewed trials showed — and when.
Urolithin A Reaches Plasma Levels
Absorption begins. Your gut doesn't need to do the work.
- Direct supplementation delivers 6× higher plasma UA than pomegranate juice — verified in Timeline's NOURISH human trial.
- Works regardless of your microbiome. ~60% of adults can't produce UA from food. Direct dosing bypasses that entirely.
- You won't feel a rush. This is not caffeine. Mitophagy is a cellular process — it works silently at first.
Mitophagy Activates — Damaged Mitochondria Begin Clearing
The PINK1/Parkin pathway is now engaged.
- Molecular signature of improved mitochondrial health was detected in skeletal muscle in the Andreux 2019 first-in-human trial (Nature Metabolism).
- The 2025 MitoImmune trial (Nature Aging) found expanded naive CD8+ T cells and increased fatty-acid oxidation capacity in just 4 weeks at 1,000mg.*
- Some users report steadier energy. This is consistent with improved mitochondrial efficiency, though the clinical trials measured biomarkers, not subjective energy.
Functional Outcomes Begin — Strength, Endurance, Recovery
This is when the human trial endpoints started showing results.
- Inflammation markers drop. The ATLAS trial showed significantly lower CRP and plasma acylcarnitines vs. placebo — measurable anti-inflammatory effect.
- Exercise recovery improves. The ENDURO trial (Sports Medicine, 2025) found lower creatine kinase (muscle damage marker) and lower perceived exertion after training.
- Muscle endurance increases. ENERGIZE (JAMA Network Open, 2022) showed improved muscle endurance — more contractions to fatigue — in adults 65+.
~12% Muscle Strength Improvement — The ATLAS Endpoint
The headline result, from the landmark 4-month RCT.
- ~12% muscle strength improvement in middle-aged adults after 4 months at 500mg — without changing their exercise routine. (ATLAS, Cell Reports Medicine, 2022)*
- Mitochondrial protein levels significantly increased. The muscle's cellular power grid was measurably rebuilt.
- This is the compounding effect. You don't feel it on day one — you feel it after the cellular turnover is complete. 90-day guarantee covers the full ramp.
6 of 10 competitor products
- Little-to-no detectable Urolithin A
- Hidden behind proprietary blends
- No published lab results or COA
- $5.3M federal judgment against 19 sellers
Foundation Gummies
- 500mg verified via HPLC every batch
- Single ingredient. No proprietary blend.
- Batch-specific COA — scan the QR code
- 90-day money-back guarantee
*ATLAS: Singh et al., Cell Reports Medicine, 2022. ENERGIZE: Liu et al., JAMA Network Open, 2022. ENDURO: Whitfield et al., Sports Medicine, 2025. MitoImmune: Denk et al., Nature Aging, 2025 (Phase 1, 1,000mg). Potency: SuppCo Tested, Sep 2025, ISO-lab verified. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Most Urolithin A Supplements Fail Lab Testing
Independent ISO-certified labs tested the 10 best-selling Urolithin A products. 6 contained little-to-no active ingredient. Here's why Foundation Gummies are different.
Every batch is tested via High-Performance Liquid Chromatography at an independent, ISO-certified lab. We verify the full 500mg clinical dose before anything ships.
No vague "lab tested" claims. We publish batch-specific COAs with the accredited lab name, test date, and exact potency reading. Scan the QR code on the bag.
Urolithin A activates mitophagy — clearing damaged mitochondria via the PINK1/Parkin pathway — but only at sufficient concentration. Underdosed products can't trigger this process.
In July 2026, a federal court permanently barred 19 sellers of fake Urolithin A supplements and awarded $5.3M in damages — confirming the potency fraud problem is real, documented, and ongoing.*
Urolithin A supplements tested by independent ISO-certified labs contained little-to-no active ingredient despite label claims.
Foundation Gummies vs. Everything Else on Amazon
Independent ISO-lab testing found 6 of 10 Urolithin A products contained little-to-no active ingredient. Here's what separates verified from vapor.
Why this table exists
A federal court awarded $5.3M against 19 sellers of fake Urolithin A (July 2026). The potency crisis is documented, not hypothetical. Every claim below is tied to published lab data or peer-reviewed trials.*
Foundation
Competitors
<0.1%
dose ✓
dose
or none
*Potency: SuppCo Tested, Sep 2025, ISO-lab verified. ATLAS: Singh et al., Cell Reports Medicine, 2022. ENERGIZE: Liu et al., JAMA Network Open, 2022. Court ruling: Case No. 1:25-cv-12913-MJJ (D. Mass.), July 2026. These statements have not been evaluated by the FDA.
The Science Behind Foundation Gummies
Every number on this page comes from peer-reviewed human clinical trials or independent ISO-certified lab testing — not marketing.
Failed independent potency testing
ISO-lab analysis found 6 of the 10 best-selling Urolithin A supplements contained little-to-no active ingredient despite label claims.
Muscle strength improvement
The ATLAS trial (Cell Reports Medicine, 2022) showed ~12% strength gains in middle-aged adults after 4 months at the 500mg dose — without changing their exercise routine.*
The verified clinical dose, every batch
Foundation Gummies deliver the exact 500mg dose used across 25+ human clinical trials and 2,200+ study participants — HPLC-verified by a third-party lab before shipment.
What You're Actually Getting — and What Most Brands Hide
Independent labs tested the 10 best-selling Urolithin A products. 6 failed.
In September 2025, SuppCo put the top Urolithin A supplements through independent ISO-certified lab analysis. The results: 6 out of 10 contained little-to-no detectable Urolithin A — despite bold label claims. Some contained less than 0.1% of the stated dose. Several carried the "Amazon's Choice" badge.
- 6 of 10 products had little-to-no active ingredient
- Some contained less than 0.1% of the label claim
- A federal court awarded $5.3M against 19 sellers of fakes
"Proprietary blend" is a legal way to hide an underdosed formula.
When a supplement label says "proprietary blend," it means they don't have to disclose individual ingredient doses. They list the names. They list total blend weight. But you never know if you're getting 500mg of Urolithin A or 5mg dusted in for the label. The FDA allows this. We don't use it.
- Blend weight shown, individual doses hidden
- "6-in-1" and "12-in-1" formulas dilute every ingredient
- Foundation Gummies: one ingredient, one dose, fully disclosed — 500mg Urolithin A
25+ human clinical trials. 2,200+ participants. Published in peer-reviewed journals.
The 500mg dose in Foundation Gummies is the same dose studied in the ATLAS trial (Cell Reports Medicine, 2022) — which showed ~12% muscle strength improvement in middle-aged adults over 4 months — and the ENERGIZE trial (JAMA Network Open, 2022), which measured improved muscle endurance in adults 65+. This is published, peer-reviewed, placebo-controlled human data.*
- ~12% muscle strength improvement at the 500mg dose (ATLAS, 2022)*
- Improved muscle endurance in adults 65+ (ENERGIZE / JAMA, 2022)*
- Reduced inflammation markers and lower CRP vs. placebo (ATLAS)*
Single ingredient. Clinical dose. Third-party verified.
Foundation Gummies contain 500mg of Urolithin A per serving — nothing else active. No proprietary blends. No fillers. No "6-in-1" dilution. Every batch is HPLC-tested by an independent ISO-certified lab, and we publish the full Certificate of Analysis with the accredited lab name, test date, and exact potency reading. Scan the QR code on the bag.
- 500mg per serving — HPLC verified before every shipment
- Published batch-specific COA — scan the QR code on the bag
- Sugar-free, vegan, non-GMO, 90-day money-back guarantee
*ATLAS: Singh et al., Cell Reports Medicine, 2022. ENERGIZE: Liu et al., JAMA Network Open, 2022. Potency: SuppCo Tested, Sep 2025, ISO-lab verified. Court ruling: Case No. 1:25-cv-12913-MJJ (D. Mass.), July 2026. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Try It Risk-Free for 90 Days
The clinical trials showed results at 4 months. Our guarantee covers the full ramp. If you don't feel the difference in strength, energy, or recovery — we'll refund every penny. No questions. No hoops.
Try Foundation Gummies →500mg verified · HPLC tested · Ships free
Questions? Good. Ask Them.
Skepticism is a sign you've been burned before. Here are the answers the other brands don't give you.
Independent ISO-certified labs (SuppCo, Sep 2025) tested the 10 best-selling Urolithin A products. 6 out of 10 contained little-to-no detectable Urolithin A — some had less than 0.1% of the label claim. Several carried the "Amazon's Choice" badge.
In July 2026, a federal court permanently barred 19 sellers of fake UA and awarded $5.3M in damages. The problem is documented, not hypothetical.
500mg of Urolithin A per 2-gummy serving — the exact dose used in the ATLAS and ENERGIZE human clinical trials. One active ingredient. No proprietary blends. No "6-in-1" dilution.
Strawberry-flavored, sugar-free, vegan, gluten-free, non-GMO. 60 gummies per bag (30 servings).
Every batch is tested via High-Performance Liquid Chromatography (HPLC) at an independent ISO-17025 certified lab — before it ships. We publish batch-specific Certificates of Analysis with the accredited lab name, test date, and exact potency reading.
Scan the QR code on the bag to see the full report for your batch.
Mitophagy is your body's process for clearing damaged mitochondria — the organelles that power every cell. Urolithin A activates this via the PINK1/Parkin pathway, first identified in Nature Medicine (2016).
Think of it as replacing broken engines so your cells can build new, functional ones. But it only works at sufficient concentration — which is why underdosed products can't trigger the process.
This is not a stimulant. Urolithin A works at the cellular level — benefits build as mitophagy clears damaged mitochondria and your body rebuilds new ones.
The ATLAS trial showed ~12% muscle strength improvement after 4 months at the 500mg dose. Some users report steadier energy within weeks, but the clinical endpoints measured outcomes at 2–4 months. Our 90-day guarantee covers the full ramp.*
Different mechanism, different evidence. NMN raises NAD+ to fuel energy metabolism. Urolithin A clears damaged mitochondria so your cells can build better ones. They target different points in the mitochondrial lifecycle.
UA also has a stronger record of functional human outcomes — the ATLAS trial measured muscle strength, not just biomarkers. And the NMN category has a documented potency crisis: ChromaDex found 64% of top-selling NMN products had less than 1% of labeled content.
Full refund. 90 days. No questions. No hoops. The clinical trials showed results at 4 months — our guarantee covers the full ramp period so you have time to feel the difference.
We can offer this because the lab report proves what's inside. A brand selling empty capsules couldn't afford this guarantee. Think about why.
Clinicians on FrontrowMD independently chose to list Foundation Gummies on their public recommendation profiles. They are not paid by the brand to do this.
They reviewed the third-party lab results, the clinical trial data, and the single-ingredient formula — then decided it met their standard. You can see who they are by clicking "Learn more" in the Clinicians' Choice badge above.